Skewness and kurtosis differed significantly between the groups with different cancer volume( t=-2.987, Z=-3.770, both P<0.05). There were significant differences in the ADC(mean), ADC(25%), ADC(50%) among patients with different T stages in the small cancer group( K=8.409, 8.187, 8.699, all P<0.05), and the up-mentioned three indices were positively correlated with T staging ( r=0.221, 0.209, 0.235, all P<0.05). There were significant differences in tumor voxels among patients with different T stages ( K=22.306, P<0.05). The tumor voxels was positively correlated with T staging ( r=0.368, P<0.05). The correlation between ADC histogram parameters and cancer stages was evaluated with Spearman test. The patients were subdivided into two groups according to cancer volume: small cancer group (<305 voxels, about 2 cm(3)) and large cancer group (≥2 cm(3)). Intra-observer repeatability was assessed by using intra-class correlation coefficients (ICC). ADC histogram of entire tumor along with the histogram parameters-the tumor voxels, ADC(mean), ADC(25%), ADC(50%), ADC(75%), skewness and kurtosis were obtained by merging all sections with SPSS 22.0 software. The area of tumor was delineated on each section of axial ADC maps to generate ADC histogram by using Image J. Methods: This retrospective study included 154 cases of NPC patientswho had received readout segmentation of long variable echo trains of MRI scan before radiation therapy. Objective: To investigate the features of apparent diffusion coefficient (ADC) histogram parameters based on entire tumor volume data in high resolution diffusion weighted imaging of nasopharyngeal carcinoma (NPC) and to evaluate its correlations with cancer stages.
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